A general synthesis of structurally diverse building blocks for preparing analogues of C-linked antifreeze glycoproteins

Authors
Eniade, A Murphy, AV Landreau, G Ben, RN
Citation
A. Eniade et al., A general synthesis of structurally diverse building blocks for preparing analogues of C-linked antifreeze glycoproteins, BIOCONJ CHE, 12(5), 2001, pp. 817-823
Citations number
40
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOCONJUGATE CHEMISTRY
ISSN journal
10431802 → ACNP
Volume
12
Issue
5
Year of publication
2001
Pages
817 - 823
Database
ISI
SICI code
1043-1802(200109/10)12:5<817:AGSOSD>2.0.ZU;2-8
Abstract
A synthetic methodology to afford unusual glycoconjugate building blocks us eful for the solid-phase synthesis of C-linked antifreeze glycoprotein (AFG P) analogues is described. Such compounds are urgently required in order to elucidate the molecular mechanism by which AFGPs function. All reactions a re general in nature and accommodate structural variation in the carbohydra te moiety, polypeptide backbone, and amino acid side chain.