Effects of the 5-HT2 receptor antagonist, ritanserin on hyperthermia and depletion of 5-HT in frontal cortex induced by a 5-HT releasing drug, p-chloroamphetamine (PCA) in mice

Authors
Yamada, J Sugimoto, Y Ohkura, M Inoue, K
Citation
J. Yamada et al., Effects of the 5-HT2 receptor antagonist, ritanserin on hyperthermia and depletion of 5-HT in frontal cortex induced by a 5-HT releasing drug, p-chloroamphetamine (PCA) in mice, BIOL PHAR B, 24(10), 2001, pp. 1195-1197
Citations number
22
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN journal
09186158 → ACNP
Volume
24
Issue
10
Year of publication
2001
Pages
1195 - 1197
Database
ISI
SICI code
0918-6158(200110)24:10<1195:EOT5RA>2.0.ZU;2-P
Abstract
Effects of the 5-HT2 receptor antagonist, ritanserin on hyperthermia and de pletion of 5-HT induced by the 5-HT-releasing drug, p-chloroamphetamine (PC A) were investigated. Ritanserin significantly suppressed PCA-induced hyper thermia in mice. PCA elicited decreases in 5-HT levels in the mouse frontal cortex. 5-HT reduction elicited by PCA was also attenuated by pretreatment with ritanserin. Since hyperthermia facilitates neurotoxicity induced by a mphetamine analogue, ritanserin may inhibit PCA-induced 5-HT neurotoxicity by inhibiting hyperthermia.