EDTA bis-(ethyl phenylalaninate): A novel transition metal-ion chelating hydroxyl radical scavenger with a potential anti-inflammatory role

Authors
Naughton, DP Grootveld, M
Citation
Dp. Naughton et M. Grootveld, EDTA bis-(ethyl phenylalaninate): A novel transition metal-ion chelating hydroxyl radical scavenger with a potential anti-inflammatory role, BIOORG MED, 11(19), 2001, pp. 2573-2575
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
19
Year of publication
2001
Pages
2573 - 2575
Database
ISI
SICI code
0960-894X(20011008)11:19<2573:EBPANT>2.0.ZU;2-D
Abstract
Conjugation of ethylenediaminetetraacetic acid (EDTA) to ethyl phenylalanin ate generates a novel radical scavenging metal-ion chelator EDTA bis-(ethyl phenylalaninate) (EBEP). The oxidation products o-, m- and p-tyrosine were isolated from hydrolysed. aqueous and aerated solutions containing EBEP. F e(II) and H2O2. Data obtained demonstrate the potential of EBEP to act as a radical scavenging, iron-ion chelating antioxidant under physiologically r elevant conditions. (C) 2001 Elsevier Science Ltd. All rights reserved.