Synthesis and acetylcholinesterase inhibition of 5-desamino huperzine A derivatives

Authors
Hogenauer, K Baumann, K Enz, A Mulzer, J
Citation
K. Hogenauer et al., Synthesis and acetylcholinesterase inhibition of 5-desamino huperzine A derivatives, BIOORG MED, 11(19), 2001, pp. 2627-2630
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
19
Year of publication
2001
Pages
2627 - 2630
Database
ISI
SICI code
0960-894X(20011008)11:19<2627:SAAIO5>2.0.ZU;2-0
Abstract
(E)- and (Z)-5-Desamino huperzine A derivatives have been synthesized using a new synthetic strategy towards the huperzine A skeleton. These derivativ es showed AChE inhibition constants in the low micromolar range and thus di splay better activity than all previously synthesized C5 derivatives. (C) 2 001 Elsevier Science Ltd. All rights reserved.