Synthesis of a reported calpain inhibitor isolated from Streptomyces griseus

Authors
Donkor, IO Sanders, ML
Citation
Io. Donkor et Ml. Sanders, Synthesis of a reported calpain inhibitor isolated from Streptomyces griseus, BIOORG MED, 11(19), 2001, pp. 2647-2649
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
19
Year of publication
2001
Pages
2647 - 2649
Database
ISI
SICI code
0960-894X(20011008)11:19<2647:SOARCI>2.0.ZU;2-9
Abstract
The reported diketopiperazine calpain inhibitor, cis-L-L-3.6-bis-(4-hydroxy benzyl)-1,4-dimethylpiperazine-2,5-dione 1, and its analogues 3 and 4 were synthesized from the corresponding amino acids. The previously assigned str ucture of 1 is confirmed but neither synthetic 1 nor its N-methylphenylalan ine analogues 3 and 4 inhibit porcine erythrocyte calpain I. (C) 2001 Elsev ier Science Ltd. All rights reserved.