Cardiomyocyte-transistor-hybrids for sensor application

An extracellular recording system has been designed for the detection of el ectrical cell signals using p-channel or n-channel field-effect transistor (FET) arrays with non-metallized gates. Signals from rat heart muscle cell were recorded by these devices and the results described on the basis of an equivalent circuit. This technique is sensitive enough to detect minute ch anges of the extracellular membrane voltage and has potential applications in drug screening. We show that known cardiac stimulants (isoproterenol, no repinephrine) and relaxants (verapamil, carbamylcholine) have characteristi c effects on the heart cells in terms of the changes of beat frequencies in the absence or presence of corresponding agents. (C) 2001 Elsevier Science B.V. All rights reserved.