Background. Sepsis and septic shock are still major causes of morbidity and
mortality in spite of the availability of powerful and broadly active anti
biotics. Methods: A prospective, open and randomized trial of the effect of
immobilized polymyxin fibers (PMX-F) on the survival of patients with seps
is throughout a follow-up period of 28 days or until discharge, if earlier,
was carried out. Ninety-eight patients were included who met at least 4 of
the criteria for systemic inflammatory response syndrome due to infection.
The patients were classified into three groups based on their Acute Physio
logy and Chronic Health Evaluation (APACHE) II score. Results: The overall
survival rate was significantly improved by using PMX-F compared to the con
trol group (41 vs. 11%) (p = 0.002). In patients with an APACHE II score le
ss than 20, treatment with PMX-F was shown to improve outcome (65 vs. 19%)
(p = 0.01). In cases of more severe sepsis with an APACHE II score of 20-29
, PMX-F still maintained efficacy in improving outcome (40 vs. 11%) (p = 0.
04). However, PMX-F treatment did not improve the survival rate in patients
with an APACHE II score of greater than 30 (survival rate 7 vs. 0%) (p=0.5
9). Conclusion: From these results, it is concluded that treatment with PMX
-F in patients with sepsis is effective and prolongs the survival rate when
applied at an early stage of sepsis. However, in severe sepsis, this thera
py does not improve the survival rate. Copyright (C) 2001 S. Karger AG, Bas
el.