Hedgehog signaling in germ cell migration

Citation
G. Deshpande et al., Hedgehog signaling in germ cell migration, CELL, 106(6), 2001, pp. 759-769
Citations number
58
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELL
ISSN journal
00928674 → ACNP
Volume
106
Issue
6
Year of publication
2001
Pages
759 - 769
Database
ISI
SICI code
0092-8674(20010921)106:6<759:HSIGCM>2.0.ZU;2-E
Abstract
The primitive gonad of the Drosophila embryo is formed from two cell types, the somatic gonad precursor cells (SGPs) and the germ cells, which origina te at distant sites. To reach the SGPs the germ cells must undergo a comple x series of cell movements. While there is evidence that attractive and rep ulsive signals guide germ cell migration through the embryo, the molecular identity of these instructive molecules has remained elusive. Here, we pres ent evidence suggesting that hedgehog (hh) may serve as such an attractive guidance cue. Misexpression of hh in the soma induces germ cells to migrate to inappropriate locations. Conversely, cell-autonomous components of the hh pathway appear to be required in the germline for proper germ cell migra tion.