The LRR proteins Capricious and Tartan mediate cell interactions during DVboundary formation in the Drosophila wing

Mechanisms to segregate cell populations play important roles in tissue pat terning during animal development. Rhombomeres and compartments in the ecto derm and imaginal discs of Drosophila are examples in which initially homog enous populations of cells come to be separated by boundaries of lineage re striction. Boundary formation depends in part on signaling between the dist inctly specified cell populations that comprise compartments and in part on formation of affinity boundaries that prevent intermingling of these cell populations. Here, we present evidence that two transmembrane proteins with leucine-rich repeats, known as Capricious and Tartan, contribute to format ion of the affinity boundary between dorsal and ventral compartments during Drosophila wing development.