Alkylation of 2-phenyl-4-quinolones: Synthetic and structural studies

Authors
Hadjeri, M Mariotte, AM Boumendjel, A
Citation
M. Hadjeri et al., Alkylation of 2-phenyl-4-quinolones: Synthetic and structural studies, CHEM PHARM, 49(10), 2001, pp. 1352-1355
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
49
Issue
10
Year of publication
2001
Pages
1352 - 1355
Database
ISI
SICI code
0009-2363(200110)49:10<1352:AO2SAS>2.0.ZU;2-Q
Abstract
The alkylation of 2-phenyl-4-quinolones was investigated and showed that th e N-alkylation versus O-alkylation is highly dependent on whether C-5 is hy droxylated or not. N-Alkylation is favoured by the presence of a 5-hydroxyl group. The synthetic and the NMR structural studies are reported.