Two new pyrrolidine alkaloids, radicamines A and B, as inhibitors of alpha-glucosidase from Lobelia chinensis Lour.

Authors
Shibano, M Tsukamoto, D Masuda, A Tanaka, Y Kusano, G
Citation
M. Shibano et al., Two new pyrrolidine alkaloids, radicamines A and B, as inhibitors of alpha-glucosidase from Lobelia chinensis Lour., CHEM PHARM, 49(10), 2001, pp. 1362-1365
Citations number
20
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
49
Issue
10
Year of publication
2001
Pages
1362 - 1365
Database
ISI
SICI code
0009-2363(200110)49:10<1362:TNPARA>2.0.ZU;2-1
Abstract
Two new pyrrolidine alkaloids, radicamines A and B were isolated as inhibit ors of alpha -glucosidase from Lobelia chinensis LOUR. (Campanulaceae). Rad icamines A and B were formulated as (2S,3S,4S,5S)-2-hydroxymethyl-3,4-dihyd roxy-5-(3-hydroxy-4-methoxyphenyl)-pyrrolidine (1) and (2S,3S,4S,5S)-2-hydr oxymethyl-3,4-dihydroxy-5-(4-hydroxyphenyl)-pyrrolidine (2) on the basis of spectroscopic analyses and chemical methods.