Novel neuronal nitric oxide synthase (nNOS) selective inhibitor, aplysinopsin-type indole alkaloid, from marine sponge Hyrtios erecta

Authors
Aoki, S Ye, Y Higuchi, K Takashima, A Tanaka, Y Kitagawa, I Kobayashi, M
Citation
S. Aoki et al., Novel neuronal nitric oxide synthase (nNOS) selective inhibitor, aplysinopsin-type indole alkaloid, from marine sponge Hyrtios erecta, CHEM PHARM, 49(10), 2001, pp. 1372-1374
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
49
Issue
10
Year of publication
2001
Pages
1372 - 1374
Database
ISI
SICI code
0009-2363(200110)49:10<1372:NNNOS(>2.0.ZU;2-X
Abstract
Two novel aplysinopsin-type indole alkaloids, 1 and 2, and three known indo le alkaloids were isolated from the marine sponge Hyrtios erecta. These com pounds exhibited selective inhibitory activity against the neuronal isozyme of nitric oxide synthase (nNOS). Furthermore, new quinolone 7 was also iso lated from the same marine sponge. The chemical structures of these new com pounds were elucidated on the basis of spectroscopic analysis.