Regioselective biomimetic oxidation of etodolac with iodosylbenzene catalyzed by halogenated and perhalogenated metalloporphyrins in dichloromethane

Authors
Chauhan, SMS Kandadai, SA Sahoo, B
Citation
Sms. Chauhan et al., Regioselective biomimetic oxidation of etodolac with iodosylbenzene catalyzed by halogenated and perhalogenated metalloporphyrins in dichloromethane, CHEM PHARM, 49(10), 2001, pp. 1375-1376
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
49
Issue
10
Year of publication
2001
Pages
1375 - 1376
Database
ISI
SICI code
0009-2363(200110)49:10<1375:RBOOEW>2.0.ZU;2-D
Abstract
The biomimetic oxidation of etodolac, an anti-inflammatory drug (1) with io dosylbenzene catalyzed by 5,10,15,20-tetraarylporphyrinatoiron(III) chlorid es TAPFe(III)CI (7a-e) in dichloromethane gives 4-hydroxyetodolac (6) and 4 -oxoetodolac (5) regioselectively in moderate yields.