Two novel cucurbitacins, neocucurbitacins A and B, from the Brazilian folkmedicine "Buchinha" (Luffa operculata) and their effect on PEBP2 alpha A and OCIF gene expression in a human osteoblast-like Saos-2 cell line

Authors
Kawahara, N Kurata, A Hakamatsuka, T Sekita, S Satake, M
Citation
N. Kawahara et al., Two novel cucurbitacins, neocucurbitacins A and B, from the Brazilian folkmedicine "Buchinha" (Luffa operculata) and their effect on PEBP2 alpha A and OCIF gene expression in a human osteoblast-like Saos-2 cell line, CHEM PHARM, 49(10), 2001, pp. 1377-1379
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
49
Issue
10
Year of publication
2001
Pages
1377 - 1379
Database
ISI
SICI code
0009-2363(200110)49:10<1377:TNCNAA>2.0.ZU;2-L
Abstract
Two novel cucurbitacins designated as neocucurbitacins A (1), possessing in hibitory activity of polyoma enhancer binding protein 2 alphaA (PEBP2 alpha A) and osteoclastogenesis-inhibitory factor (OCIF) gene expression in human osteoblast-like cells, and B (2) were isolated from the fruit of Luffa ope rculata. Their structures have been determined by extensive spectroscopic i nvestigation.