New and easy route to primary cyclopropylamines from nitriles

Authors
Bertus, P Szymoniak, J
Citation
P. Bertus et J. Szymoniak, New and easy route to primary cyclopropylamines from nitriles, CHEM COMMUN, (18), 2001, pp. 1792-1793
Citations number
15
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
18
Year of publication
2001
Pages
1792 - 1793
Database
ISI
SICI code
1359-7345(20010921):18<1792:NAERTP>2.0.ZU;2-Y
Abstract
Starting from readily available substrates, we have developed a new synthes is of primary cyclopropylamines. The reaction involves a cooperative Ti(II) - and Lewis acid-mediated coupling of alkanenitriles with Grignard reagents .