Effects of cefepime and meropenem on the gastrointestinal colonization of surgical patients by Candida albicans

Background: The study evaluated the effects of cefepime and meropenem on th e gastrointestinal (GI) colonization of surgical patients by Candida albica ns. Patients and Methods: Twenty adult surgical patients who received intra venously either of these antibiotics as monotherapy for the treatment of an existing infection were studied prospectively. Ten patients received cefep ime (2.0 g twice a day), and another ten meropenem (1.0 g every 8 h) for 7 days. Quantitative stool cultures for C. albicans were performed immediatel y before, at the end, and 1 week after the end of antibiotic treatment. Res ults: Both antibiotics increased the GI colonization of patients by Candida . Meropenem caused a higher increase (2.0 log(10) CFU/g of stool) as compar ed to cefepime (1.7 log(10) CFU/g of stool). However, these increases were statistically not significant. Conclusion: Cefepime and meropenem when give n to sensitive patients do not increase significantly the risk of Candida: infection originating in the GI tract. Copyright (C) 2001 S. KargerAG, Base l.