Pmb. Van Tilburg et al., Emergence of rifampin-resistant Streptococcus pneumoniae as a result of antimicrobial therapy for penicillin-resistant strains, CLIN INF D, 33(8), 2001, pp. E93-E96
A multidrug-resistant strain of Streptococcus pneumoniae was isolated in Th
e Netherlands during a nosocomial outbreak among 36 patients who mainly had
chronic obstructive pulmonary disease. After the commencement of barrier n
ursing and short-term ceftriaxone-rifampin eradication therapy, the epidemi
c ceased. However, eradication therapy failed in 3 patients, and follow-up
investigation of these patients showed the emergence of rifampin-resistant
isolates.