Acute disseminated encephalomyelitis following aseptic meningoencephalitis

A previously healthy 50-year-old man developed aseptic meningoencephalitis with clinical manifestations including fever, headache, seizure, Wernicke a phasia, right hemiplegia, and blindness in the left eye. One and one-half m onths after remission of meningoencephalitis, marked ataxia and psychiatric symptoms became apparent. Magnetic resonance imaging revealed multiple new lesions involving the basal ganglia, thalamus, white matter, and cerebellu m. Despite these developments, cerebrospinal fluid findings continued to im prove except for excessive content of myelin basic protein. Within 2 weeks, steroid therapy dramatically resolved the ataxic symptoms and disseminated lesions. (C) 2001 Elsevier Science B.V. All rights reserved.