Cerebral vein thrombosis and prothrombin gene (G20210A) mutation

Recently, prothrombin gene mutation G20210A has been associated with elevat ed thrombosis risk and rarely with cerebral vein thrombosis (CVT). Three pa tients are described who had this genetic predisposition and who developed CVT in an unusual constellation with other factors. In the first patient, t he intake of valproic acid (VPA) may have played an aggravating role in the development of CVT, in the second patient diagnosis of coagulation disorde r was made during pregnancy consultation 6 years after CVT, in the third pa tient the CVT occurred at the age of 78 years. In patients with CVT, coagul ation-examinations should include tests for the prothrombin gene (G20210A) mutation. (C) 2001 Elsevier Science B.V. All rights reserved.