Vascular disease prevalence in diabetic patients in China: standardised comparison with the 14 centres in the WHO multinational study of vascular disease in diabetes

Aims/hypothesis. Rates of vascular complications of diabetes in a cohort of mainland Chinese patients with diabetes, ascertained and examined by simil ar methodology, are compared with those of the WHO Multinational Study of V ascular Disease in Diabetes (WHO MSVDD). Methods. The standardised procedures carried out in the WHO MSVDD were foll owed in assembling and examining a Chinese cohort of 447 diabetic patients recruited in Beijing and Tianjin [2]. Results. Compared with the WHO MSVDD centres, the Chinese cohort was slight ly older, had a shorter duration of known diabetes and had fewer insulin-tr eated patients. Arterial pressure, total blood cholesterol and body mass in dex were substantially lower. Large vessel disease rate for age, sex and du ration adjusted data (17.9%) was about half that of the combined WHO MSVDD centres (33.5% p < 0.001). However, retinopathy (47.4% vs 35.8% p < 0.001) and proteinuria (57.1 vs 24.9% p < 0.001) rates were significantly higher. Conclusion/interpretation. Relatively low arterial pressures and blood chol esterol are likely contributors to the notably low arterial disease rates i n this Chinese diabetic cohort; they reflect low rates in the Chinese mainl and general population and resemble the Tokyo and Hong Kong centres of the WHO MSVDD. The high rates of retinopathy and proteinuria could relate to la ter diagnosis, degree of hyperglycaemia and/or increased susceptibiltiy to microangiopathy.