TREATMENT WITH OFLOXACIN OF PULMONARY EXA CERBATION OF CYSTIC-FIBROSIS IN CHILDREN AND JUVENILES

In infectious respiratory exacerbations of cystic fibrosis, multi-resi stant bacteria present the physician with a major therapeutic problem. Up to now, the possibilities of antibiotic therapy have frequently pr oved inadequate, thus making ofloxacin, from the group of more recent DNA gyrase inhibitors, a highly attractive alternative in oral therapy (cf. 13). This is attributable to its highly favourable kinetic prope rties and a wide spectrum of activity (incl. pseudomonas). The overall successful results of therapy on 25 patients (66 episodes) with highe r ofloxacin dosages and in somes cases extended treatment periods show that the possible benefits of short-term therapy with ofloxacin in ju venile cystic fibrosis patients significantly outweight the risks of a therapeutic alternative.