Open surgery in a severely anemic patient may be complicated by a subs
tantial blood loss from a large incision and subsequent poor wound hea
ling secondary to the anemia. We report our success in performing a sp
lenectomy laparoscopically in a profoundly anemic patient. A 50-year-o
ld white male Jehovah's Witness who was HIV positive was referred for
splenectomy after he developed profound, worsening anemia secondary to
hypersplenism that was refractory to medical management. His preopera
tive hemoglobin and hematocrit levels were 2.7 g/dl and 8.8%, respecti
vely, but his religious beliefs precluded transfusion, A laparoscopic
splenectomy by the posterior gastric approach was performed. The patie
nt tolerated the surgery well and experienced no additional morbidity.
On postoperative day 7, his hemoglobin and hematocrit were 6.8 g/dl a
nd 22%, respectively. We conclude that laparoscopic splenectomy is an
attractive procedure in a severely anemic patient who requires splenec
tomy and refuses blood transfusion.