IN-VITRO EVALUATION OF ANTIFUNGAL PROPERTIES OF 8.0.4'-NEOLIGNANS

Eighteen racemic 8.O.4'-neolignans with six different substitution pat terns in rings A and B, in their ketone and in their erythro and three alcoholic forms, were evaluated for antifungal activity by the agar d ilution method. Only the alcohols exhibited a broad spectrum of activi ties against Microsporum canis, Microsporum gypseum, Tricophyton menta grophytes, Tricophyton rubrum, and Epidermophyton floccosum. 7-hydroxy -1'-allyl-3'5'-dimethoxy-8.O.4'-neolignan (11) was the most active com pound in the series, and E. floccosum was the most susceptible species .