HIV-INHIBITORY NATURAL-PRODUCTS .36. MICHELLAMINES-D-F, NEW HIV-INHIBITORY DIMERIC NAPHTHYLISOQUINOLINE ALKALOIDS, AND KORUPENSAMINE-E, A NEW ANTIMALARIAL MONOMER, FROM ANCISTROCLADUS-KORUPENSIS

Authors
HALLOCK YF MANFREDI KP DAI JR CARDELLINA JH GULAKOWSKI RJ MCMAHON JB SCHAFFER M STAHL M GULDEN KP BRINGMANN G FRANCOIS G BOYD MR
Citation
Yf. Hallock et al., HIV-INHIBITORY NATURAL-PRODUCTS .36. MICHELLAMINES-D-F, NEW HIV-INHIBITORY DIMERIC NAPHTHYLISOQUINOLINE ALKALOIDS, AND KORUPENSAMINE-E, A NEW ANTIMALARIAL MONOMER, FROM ANCISTROCLADUS-KORUPENSIS, Journal of natural products, 60(7), 1997, pp. 677-683
Citations number
24
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
60
Issue
7
Year of publication
1997
Pages
677 - 683
Database
ISI
SICI code
0163-3864(1997)60:7<677:HN.MNH>2.0.ZU;2-#
Abstract
New monomeric (korupensamine E, 6) and dimeric (michellamines D-F, 7-9 ) naphthylisoquinoline alkaloids have been isolated from exracts of th e tropical liana Ancistrocladus korupensis. Structures were determined by spectroanalytical methods, and stereochemistry was defined through NOE correlations, chemical degradation, and CD spectroscopy. Michella mines D-F exhibited in vitro HIV-inhibitory activity comparable to mic hellamine B, and korupensamine E exhibited in vitro antimalarial activ ity comparable to korupensamines A-D.