SODWANONE-K, SODWANONE-L, AND SODWANONE-M - NEW TRITERPENES FROM THE MARINE SPONGE AXINELLA-WELTNERI

Three new triterpenes, sodwanones M, K, and L (4, 5, 6), together with three known sodwanones (A, B, and D) have been isolated from the spon ge Axinella weltneri from the Comoros Islands, in the Indian Ocean. Th e three new structures were determined by interpretation of NMR spectr a and, in the case of sodwanone K, also by oxidation to the known sodw anone D. Sodwanone M, the major isolated compound, was found to be cyt otoxic to P-388 murine leukemia cells at a concentration of 1 mu g/mL.