INHIBITORY EFFECT OF DEHYDROEVODIAMINE AND EVODIAMINE ON NITRIC-OXIDEPRODUCTION IN CULTURED MURINE MACROPHAGES

Authors
CHIOU WF SUNG YJ LIAO JF SHUM AYC CHEN CF
Citation
Wf. Chiou et al., INHIBITORY EFFECT OF DEHYDROEVODIAMINE AND EVODIAMINE ON NITRIC-OXIDEPRODUCTION IN CULTURED MURINE MACROPHAGES, Journal of natural products, 60(7), 1997, pp. 708-711
Citations number
17
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
60
Issue
7
Year of publication
1997
Pages
708 - 711
Database
ISI
SICI code
0163-3864(1997)60:7<708:IEODAE>2.0.ZU;2-V
Abstract
Possible antiinflammatory effects of dehydroevodiamine (1) and evodiam ine (2) were examined by assessing their effects an NO production in t he murine macrophage-like cell line RAW 264.7. The results indicated t hat both 1 and 2 inhibited the IFN-gamma/LPS-stimulated NO production in a concentration-dependent manner. However, 1 appeared to inhibit NO production by interfering not only with the priming signal initiated by IFN-gamma but also with iNOS protein synthesis, while 2 affected th e former only.