NEW INDOLE-DERIVATIVES WITH FREE-RADICAL SCAVENGING ACTIVITY FROM AGROCYBE-CYLINDRACEA

Authors
KIM WG LEE IK KIM JP RYOO IJ KOSHINO H YOO ID
Citation
Wg. Kim et al., NEW INDOLE-DERIVATIVES WITH FREE-RADICAL SCAVENGING ACTIVITY FROM AGROCYBE-CYLINDRACEA, Journal of natural products, 60(7), 1997, pp. 721-723
Citations number
17
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
60
Issue
7
Year of publication
1997
Pages
721 - 723
Database
ISI
SICI code
0163-3864(1997)60:7<721:NIWFSA>2.0.ZU;2-W
Abstract
Two new indole derivatives were isolated as free radical scavengers fr om the MeOH extract of Agrocybe cylindracea. The structures of these c ompounds were determined to be 6-hydroxy-1H-indole-3-carboxaldehyde (1 ) and 6-hydroxy-1H-indole-3-acetamide (2) on the basis of spectroscopi c studies. Compounds 1 and 2 inhibited lipid peroxidation in rat liver microsomes, with IC50 values of 4.1 and 3.9 mu g/mL, respectively.