Oxidation of D-[U-C-14] glucose and [1,12-C-14] dodecanedioic acid by pancreatic islets from Goto-Kakizaki rats

In pancreatic islets from hereditarily diabetic GK rats, [1,12-C-14] dodeca nedioic acid (5.0 mM) was oxidized at a rate representing about 5% of that of D-[U-C-14] glucose (8.3 mM). Dioic acid and hexose failed to exert any s ignificant reciprocal effects on their respective oxidation. The production Of (CO2)-C-14 from [1,12-14C] dodecanedioic acid was proportional to its c oncentration in the 0.2-5.0 mM range. These results were essentially compar able to those obtained in islets from control rats. They extend, therefore, to GK rats the knowledge that dodecanedioic acid acts as a nutrient in pan creatic islet cells.