Wj. Malaisse et al., Oxidation of D-[U-C-14] glucose and [1,12-C-14] dodecanedioic acid by pancreatic islets from Goto-Kakizaki rats, HORMONE MET, 33(8), 2001, pp. 463-466
In pancreatic islets from hereditarily diabetic GK rats, [1,12-C-14] dodeca
nedioic acid (5.0 mM) was oxidized at a rate representing about 5% of that
of D-[U-C-14] glucose (8.3 mM). Dioic acid and hexose failed to exert any s
ignificant reciprocal effects on their respective oxidation. The production
Of (CO2)-C-14 from [1,12-14C] dodecanedioic acid was proportional to its c
oncentration in the 0.2-5.0 mM range. These results were essentially compar
able to those obtained in islets from control rats. They extend, therefore,
to GK rats the knowledge that dodecanedioic acid acts as a nutrient in pan
creatic islet cells.