Synthesis and antimicrobial activity of N-(substitutedphenyl)-N '-[ 1,2,3,4-tetrahydro-2-oxido-1,3,2-benzodiazaphosphorine-2-yl] ureas

Authors
Rao, LN Reddy, CD Reddy, BS
Citation
Ln. Rao et al., Synthesis and antimicrobial activity of N-(substitutedphenyl)-N '-[ 1,2,3,4-tetrahydro-2-oxido-1,3,2-benzodiazaphosphorine-2-yl] ureas, I J CHEM B, 40(9), 2001, pp. 817-821
Citations number
22
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
ISSN journal
03764699 → ACNP
Volume
40
Issue
9
Year of publication
2001
Pages
817 - 821
Database
ISI
SICI code
0376-4699(200109)40:9<817:SAAAON>2.0.ZU;2-B
Abstract
N-(Substitutedphenyl)-N'-[1,2,3,4-tetrahydro-2-oxido-1,3,2-benzodiazaphosph orine-2-yl] ureas 5 which are substituted ureas of the type RR'P(O)NHC(O)NR "R"' have been synthesized from reactions of 2-aminobenzylamine 2 with chlo rides of arylcarbamidophosphoric acids 4 in the presence of triethylamine a t 40-45 degreesC. IR, H-1 and P-31 NMR and mass spectra are recorded and an alysed. The title compounds have been screened for their antifungal and ant ibacterial activities. All of these compounds exhibit significant activity in the assays.