Synthesis and antimicrobial activity of 2-substituted-2,3-dihydro-1H-naphtho-[1,8-de]-1,3,2-diazaphosphorine 2-oxides/sulfides

Authors
Venugopal, M Reddy, CD Bavaji, M
Citation
M. Venugopal et al., Synthesis and antimicrobial activity of 2-substituted-2,3-dihydro-1H-naphtho-[1,8-de]-1,3,2-diazaphosphorine 2-oxides/sulfides, I J CHEM B, 40(9), 2001, pp. 822-827
Citations number
22
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
ISSN journal
03764699 → ACNP
Volume
40
Issue
9
Year of publication
2001
Pages
822 - 827
Database
ISI
SICI code
0376-4699(200109)40:9<822:SAAAO2>2.0.ZU;2-2
Abstract
Several 2-alkylcarbamato/thiocarbamato/arylcarbamido/trichloromethy/bis(2-c hloro-ethyl)amino/chloroethoxy/aryloxy-2,3-dihydro-1H-naphtho-[1,8-de]-1,3, 2-diazaphosphorine 2-oxides/sulfides (4 and 6) are synthesized by reacting equimolar quantities of 1,8-diamino-naphthalene 1 with various dichlorophos phinyl carbamates/thiocarbamates/arylcarbamides 3a-1, trichloromethylphosph onic dichloride 5a, bis(2-chloroethyl)phosphoramidic dichloride 5b, O-2-chl oroethyl phosphoryl chloride 5c and arylphosphorothioic dichlorides 5d-e in the presence of triethylamine at 45-65 degreesC. Their IR, H-1, C-13, P-31 NMR and mass spectral data are discussed. All these compounds are found to have significant antifungal and antibacterial activity.