Synthesis, antimicrobial and antituberculosis activities of N-bridged heterocycles

The reactions of 3-[(((alpha -phenyl/methyl)benzylidene)amino)oxy]methyl/et hyl-4-amino-5-mercapto-4(H)-1,2,4-triazoles 1a-d, with various aliphatic/ar omatic acids 2a-d-5a-d, oxalic acid 6a-d, cyanogen bromide 7a-d, carbon dis ulphide 8a-d, hydrazine hydrate (99%) 9a-d, monochloroacetic acid 10a-d, ph enacyl bromide 11a-d, benzoin 12a-d, dimidone 13a-d and chalcone 14a-d are described. The characterisation of the compounds have been done on the basi s of elemental analysis and spectral (IR, (HNMR)-H-1 and mass) data. All th e newly synthesised compounds have been screened for antimicrobial activity against B. cirroflagellosus, E. coli, A. niger and R. bataticola. Most of the compounds have also been screened for antituberculosis activity against M. tuberculosis, H37Rv strain. Results of antimicrobial screening revealed that majority of the newly synthesised N-bridged heterocycles exhibit bett er antimicrobial activity than the standards cotrimoxazole and fluconazole. A few of the compounds exhibit significant antituberculosis activity in co mparison with rifampin, the standard used.