Drotaverine hydrochloride vs. valethamate bromide in acceleration of labor

Objectives: To compare the efficacy and safety of drotaverine hydrochloride and valethamate bromide in shortening the duration of labor. Methods: In a randomized controlled trial of 150 nulliparous women in established labor with cervical dilation of 4 cm, 50 women were given drotaverine (group I), 50 women were given valethamate (group II) and another 50 women were not gi ven any medication (group III). Duration of labor, mode of delivery, side e ffects, and neonatal outcome were measured in all cases. Appropriate non-pa rametric tests and chi (2) tests were used for assessment of statistical si gnificance. Results: In the three groups, 100%, 96% and 46% women delivered within 6 h, respectively. The injection-to-delivery interval was significa ntly reduced in the drotaverine group (193.96 min) in contrast to the valet hamate group (220.68 min) and control group (412.84 min). The rate of cervi cal dilation was highest in the drotaverine group (2.04 cm/h) compared with the valethamate bromide group (1.86 cm/h) and control group (1.01 cm/h). T here were no major maternal or fetal adverse effects in any group, but mino r side effects were more common in the valethamate group, Conclusion: Both intramuscular drotaverine hydrochloride and valethamate bromide are effecti ve in acceleration of labor; however, drotaverine accelerates labor more ra pidly and is associated with less side effects. (C) 2001 International Fede ration of Gynecology and Obstetrics. All rights reserved.