Dosing time-dependent effect of trandolapril on the prevention of cardiac hypertrophy in rats with aortic banding

Authors
Sugimoto, K Ohmori, M Kawaguchi, A Tsuruoka, S Fujimura, A
Citation
K. Sugimoto et al., Dosing time-dependent effect of trandolapril on the prevention of cardiac hypertrophy in rats with aortic banding, JPN J PHARM, 87(1), 2001, pp. 86-89
Citations number
13
Categorie Soggetti
Pharmacology & Toxicology
Journal title
JAPANESE JOURNAL OF PHARMACOLOGY
ISSN journal
00215198 → ACNP
Volume
87
Issue
1
Year of publication
2001
Pages
86 - 89
Database
ISI
SICI code
0021-5198(200109)87:1<86:DTEOTO>2.0.ZU;2-K
Abstract
Trandolapril was given to male Wistar rats with aortic banding at 10 AM or 10 PM for 6 weeks to examine the influence of dosing time on the developmen t of left ventricular mass (LVM). Aortic banding increased the LVM compared with the sham-operated animals (P <0.01). Trandolapril (1 mg/kg) at 10 AM reduced LVM (1.74 +/- 0.04 [S.E.M.] mg/g) more than the dosing at 10 PM (1. 92 +/- 0.04 mg/g, P <0.05), suggesting that trandolapril has a dosing time- dependent effect in the prevention of cardiac hypertrophy in rats with aort ic banding.