ENDODERMAL SINUS TUMORS IN THE HEAD AND NECK REGION

Extragonadal germ cell tumors of the head and neck region account for only 5% of all benign and malignant germ cell tumors. Endodermal sinus tumors (EST) of the head and neck region are rare. We report three pa tients with EST of head and neck region over a period of 10 years; the primary sites of tumor were orbit, maxillofacial region and retroauri cular region. Histopathological examination revealed malignant teratom a with predominant endodermal sinus pattern in two, and pure EST in on e patient. Serum alpha fetoprotein (AFP) was elevated in all three pat ients. Two patients had initial surgery but did not receive adjuvant c hemotherapy, as the parents refused it. Partial remission was achieved in the other patient who received chemotherapy (cisplatin, bleomycin and vinblastin) and the patient died of infection after four courses o f chemotherapy. (C) 1997 Wiley-Liss, Inc.