The diffuse biliary or pancreatic papillomatosis is a rare pathology. Repor
ted cases in the literature underscore the difficulties of preoperative dia
gnosis of these lesions, their extensive nature, their tendency to relapse,
and their malignant potential. The case that we report differs by the isol
ated involvement of the biliary tract and by the increasing role of imaging
(MRCP) for diagnosis and follow-up.