EFFECT OF NISOLDIPINE ON RED-CELL DEFORMABILITY AND PLATELET-AGGREGATION IN STROKE PATIENTS

Authors
KUZUYA F HAYAKAWA M
Citation
F. Kuzuya et M. Hayakawa, EFFECT OF NISOLDIPINE ON RED-CELL DEFORMABILITY AND PLATELET-AGGREGATION IN STROKE PATIENTS, Arzneimittel-Forschung, 44-2(11), 1994, pp. 1214-1216
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
44-2
Issue
11
Year of publication
1994
Pages
1214 - 1216
Database
ISI
SICI code
0004-4172(1994)44-2:11<1214:EONORD>2.0.ZU;2-L
Abstract
Reduced red cell deformability and increased platelet aggregability ar e assumed to contribute to various ischemic diseases, and it has been postulated that these abnormalities may be improved by drug treatment. In this study, the effect of nisoldipine (Bay K 5552, CAS 63675-72-9) on red cell deformability and platelet aggregation in patients with c hronic ischemic cerebrovascular disease and hypertension was examined. Administration of nisoldipine for 4 weeks caused a significant improv ement of red cell deformability and platelet aggregability without cau sing any adverse effects.