Risk factors for asthma in urban Ghana

Background: Asthma is increasing in prevalence and severity in Africa. Prev ious studies have suggested that the prevalence of atopy in West Africa was low. Objective: We sought to investigate the risk factors for asthma in Ghanaian school children. Methods: Fifty children (age range, 9-16 years) with a physician diagnosis of asthma and asthma symptoms within the previous 12 months and 50 age- and sex-matched healthy control subjects were randomly selected and evaluated by means of questionnaire, skin testing, total and specific IgE measurement s, and allergen level measurements from bed dust samples (mite, cat, dog, a nd cockroach). Results: Asthmatic children were exposed to higher levels of mite allergens than were control children (geometric mean, 19 mug/g (95% CI, 13.6-26.5] v s 11.2 mug/g [7.4-15.7]; P < .05). Cat and dog allergen levels were low. Th ere was a marked dissociation between skin test responses and the presence of specific IgE to cat and dog (CAP method). However, 84% of subjects, with positive cat dander-specific IgE levels in cat CAP tests and negative skin test responses did not have Fel d I-specific IgE (chimeric ELISA). In the univariate analysis significant associations with the patient group were fo und for sensitization to mite (odds ratio [OR], 9.3; 95% CI, 3.7-23.4) and cockroach (OR, 3.9; 95% CI, 1.3-11.6), inner-city residence (OR, 3.5; 95% C I, 1.4-8.9), asthma in family member (OR, 3.5; 95% CI, 1.4-9.0), low (<5) p osition in sibship (OR, 3.6; 95% CI, 1.2-11), presence of smoker in home (O R, 3.7; 95 % CI, 1.2-11.9), small household size (OR, 0.57; 95% CI, 0.35-0. 93), and use of electricity as domestic fuel (OR, 0.34; 95% Cl, 0.12-0.97). In the multivariate analysis sensitization to mites remained the strongest risk factor associated with the asthmatic group (OR, 10.4; 95% CI, 3.5-30. 9). The other significant associations were inner-city residence (OR, 4.8; 95 % CI, 1.5-5.2), sensitization to cockroach (OR, 4.9; 95% CI, 1.3-18.6), and position in sibship of less than 5 (OR, 6.3; 95 % CI, 1.3-29.4). Conclusion: Sensitization to dust mite and cockroach allergens, inner-city residence, and low position in sibship were independent risk factors for as thma in Ghanaian children.