Experimental model of hemorrhagic shock in swine

A hemorrhagic shock was created in 12 hybrid swine under general anaesthesi a, by bleeding Of 80% of total blood volume and the duration Of the shock w as 90 minutes. Circulatory parameters progressively decreased (p < 0.005) e xcept for heart rate that progressively increased. End-tidal CO, showed a M odest increase of about 7% during the shock between 30 and 60 min after ble eding. Cardiac output and index significantly (P < 0.0005) decreased in the first 30 min. Systemic vascular resistance trend showed an early fall at t he beginning of bleeding, while pulmonary vascular resistance increased (p < 0.01) following an almost linear pattern for 60 min of shock. Oxygen deli very index progressively decreased, while oxygen consumption index remained unchanged. To SUM Up, this experimental model can be used to evaluate the Most reliable monitoring instruments.