Solubilities of zopiclone and nimodipine in supercritical carbon dioxide

Authors
Medina, I Bueno, JL
Citation
I. Medina et Jl. Bueno, Solubilities of zopiclone and nimodipine in supercritical carbon dioxide, J CHEM EN D, 46(5), 2001, pp. 1211-1214
Citations number
13
Categorie Soggetti
Chemistry,"Chemical Engineering
Journal title
JOURNAL OF CHEMICAL AND ENGINEERING DATA
ISSN journal
00219568 → ACNP
Volume
46
Issue
5
Year of publication
2001
Pages
1211 - 1214
Database
ISI
SICI code
0021-9568(200109/10)46:5<1211:SOZANI>2.0.ZU;2-B
Abstract
Solubility measurements for two pharmaceutical products, zopiclone and nimo dipine, in supercritical carbon dioxide are reported over the temperature r ange (313 to 333) K and pressure range (10.0 to 25.0) MPa. The solubilities were measured using a continuous flow apparatus. The measured mole fractio ns of the two compounds in supercritical carbon dioxide are correlated with the density of the pure solvent, and the solubilities are correlated using the model proposed by Chrastil.