Fast C-13-glucose metabolite mapping in rat brain using H-1 echo planar spectroscopic imaging technique at 2T

For fast C-13 metabolite mapping in rat brains, H-1-detected C-13 NMR spect roscopy using gradient-enhanced heteronuclear multiple-quantum coherence an d H-1 echo planar spectroscopic imaging were combined. C-13 glucose and 3-/ 4-C-13-Glu/Gln images of rat brain were successfully constructed with 35-mi nute temporal resolution under a 2T magnetic field. In the ischemic region of the suture middle cerebral artery occlusion model, glucose and Glu/Gln s ignals decreased and lactate signals appeared. (C) 2001 Wiley-Liss, Inc.