Evaluation of nonperfused myocardial ischemia with MRI and an intravascular USPIO contrast agent in an ex vivo pig model

Citation
T. Bjerner et al., Evaluation of nonperfused myocardial ischemia with MRI and an intravascular USPIO contrast agent in an ex vivo pig model, J MAGN R I, 12(6), 2000, pp. 866-872
Citations number
28
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging
Journal title
JOURNAL OF MAGNETIC RESONANCE IMAGING
ISSN journal
10531807 → ACNP
Volume
12
Issue
6
Year of publication
2000
Pages
866 - 872
Database
ISI
SICI code
1053-1807(200012)12:6<866:EONMIW>2.0.ZU;2-O
Abstract
The ultrasmall superparamagnetic iron oxide (USPIO) preparation NC100150 In jection (Clariscan; Nycomed Imaging, Oslo, Norway) was tested for its abili ty to delineate nonperfused myocardium under steady-state conditions. An ex perimental animal model of focal myocardial ischemia induced by ligation of the distal part of the left anterior descending artery was used. The contr ast agent was administered in four doses: 0, 4, 8, and 12 mg Fe/kg body wei ght. Magnetic resonance examination ex vivo, including T1-, T2-, and T2*-we ighted sequences, was performed. Nonperfused myocardium was determined by f luorescein. The best delineation of nonperfused myocardium was found with a T1-weighted inversion recovery/turbo spin-echo sequence and doses of 4 and 8 mg Fe/kg body weight, where 95% of the volume was discernible at the dos e of 4 mg Fe/kg body weight. The results suggest that steady-state imaging by T1-weighted sequence with the use of NC100150 Injection to delineate non perfused myocardium is feasible. (C) 2000 Wiley-Liss, Inc.