CH-19 Sweet, nonpungent cultivar of red pepper, increased body temperaturein mice with vanilloid receptors stimulation by capsiate

We investigated the effect of CH-19 Sweet, a nonpungent cultivar of red pep per, and capsiate, a nonpungent capsaicin analog found in CH-19 Sweet on bo dy temperature in mice. The body temperature was recorded from conscious an d unrestrained mice by use of a telemetry system. The body temperature in t he mice administered CH-19 Sweet was higher than in the mice administered C alifornia-Wandar, which contains no capsiate or capsaicin. The body tempera ture in the mice administered capsiate was higher than in the mice administ ered the vehicle. Furthermore, we injected capsazepine, a specific antagoni st of vanilloid receptors, into the peritoneal cavity and orally administer ed capsiate via a stomach tube to mice. The body temperature in the mice pr etreated with capsazepine was lower than in the mice injected with the vehi cle. This result suggested that capsazepine suppressed the rise in body tem perature induced by capsiate administration. In conclusion, CH-19 Sweet inc reased body temperature, and this effect may be induced by the vanilloid re ceptors' stimulation of capsiate.