11-Demethylcyclosporins exhibit a single conformation in methanol and dimethylsulfoxide

Authors
Sedmera, P Jegorov, A Buchta, M Cvak, L
Citation
P. Sedmera et al., 11-Demethylcyclosporins exhibit a single conformation in methanol and dimethylsulfoxide, J PEPT RES, 58(3), 2001, pp. 229-236
Citations number
39
Categorie Soggetti
Biochemistry & Biophysics
Journal title
JOURNAL OF PEPTIDE RESEARCH
ISSN journal
1397002X → ACNP
Volume
58
Issue
3
Year of publication
2001
Pages
229 - 236
Database
ISI
SICI code
1397-002X(200109)58:3<229:1EASCI>2.0.ZU;2-4
Abstract
NMR studies showed that 11-demethylcyclosporin A (cyclosporin E) and 11-dem ethylcyclosporin B exist as single species both in polar and nonpolar solve nts. They adopt the same conformation that was found in the solid state.