Ta. Zamoshchina et al., DESTRUCTION OF RAPHE AND LOCUS-COERULEUS AND CIRCADIAN-RHYTHMS OF RATBEHAVIORAL ACTIVITY, Zurnal vyssej nervnoj deatelnosti im. I.P. Pavlova, 47(3), 1997, pp. 577-583
The electrolytic lesions of Raphe or Locus coeruleus (I = 1-1,5 mA, 20
sec, with a change in polarity) produce a destabilization in the circ
adian rhythms of the active searching behaviour (tested in the ''open
field'') in rats kept under conditions of natural illumination in the
period of the winter or summer solstice. The daily or circadian compon
ents are substituted, respectively, for the ultra- or infradian rhythm
s. If the animals are kept for 10 days under 24-h light or dark condit
ions, the serotoninergic or noradrenergic deficit delays the formation
of free-running rhythms.