Objective. To determine whether ultrasonographic detection of acardiac fetu
ses and diagnostic accuracy of related malformations improve with complemen
tary use of two-dimensional ultrasonography, three-dimensional ultrasonogra
phy, and Doppler scanning. Methods. Three pregnant women with multifetal ge
stations who were found to have discordant fetuses on initial two-dimension
al ultrasonographic scanning were subsequently scanned with three-dimension
al ultrasonography and color Doppler ultrasonography. Results. Although the
possibility of acardiac fetuses was entertained in all cases after two-dim
ensional ultrasonographic scanning, the diagnosis was confirmed, and the ac
curacy and extent of fetal malformations were established with three-dimens
ional ultrasonography and color Doppler scanning. Two of the women had twin
gestations, and the third woman had a triplet gestation. Among the women w
ith twin gestations, I donor twin had no abnormalities, and the other donor
twin had a diagnosis of arthrogryposis and gastroschisis. The woman with t
riplets had 1 acardiac fetus; the donor fetus was anencephalic; and the thi
rd fetus had alobar holoprosencephaly. Conclusions. Complementary use of tw
o-dimensional ultrasonography, three-dimensional ultrasonography, and color
Doppler scanning improves diagnostic accuracy and the ability to evaluate
the extent and severity of organ compromise in pregnancies complicated by a
cardiac fetuses.