Antiinfectious prophylaxis in asplenia.

Citation
Sw. Eber et al., Antiinfectious prophylaxis in asplenia., KLIN PADIAT, 213, 2001, pp. A84-A87
Citations number
13
Categorie Soggetti
Pediatrics
Journal title
KLINISCHE PADIATRIE
ISSN journal
03008630 → ACNP
Volume
213
Year of publication
2001
Pages
A84 - A87
Database
ISI
SICI code
0300-8630(200109)213:1<A84:APIA>2.0.ZU;2-O
Abstract
Asplenia in childhood may be congenital (e.g. Ivemark-syndrome) or acquired (functional hyposplenism in sickle cell disease; after splenectomy or bone marrow transplantation). Hereditary spherocytosis is the most common indic ation for splenectomy in childhood. Virtually every patient without spleen has a significantly increased risk of severe postsplenectomy infection (mos tly caused by Streptococcus pneumoniae). Therefore, vaccinations against pn eumococci, haemophilus influenzae and, under certain circumstances, meningo cocci are recommended. In addition a continuous prophlyaxis with antibiotic s should be performed for at least three years (or even longer depending on the disease) after splenectomy followed by lifelong interventional applica tion of broad spectrum antibiotics in case of any unclear infection or high fever. This prophylaxis must be started as early as four months of age in sickle cell disease. in future the use of penicillin may be hampered by the growing resistance of pneumococci. Due to this fact the indication for spl enectomy in childhood should be restricted to patients with hematologic dis ease (spherocytosis and other hemolytic anemias, chronic ITP etc.) and mode rate to severe symptoms. It is unclear whether partial splenectomy for sphe rocytosis (and other hemolytic anemias) is an alternative regarding both lo nglasting reduction of hemolysis and prevention of severe infection. After trauma every effort should be undertaken to preserve a splenic remnant.