Juvenile and adolescent "Chronic Recurrent Multifocal Osteomyelitis" (CRMO)
is described on the basis of literature and analysis of 43 own cases (23 c
ases in children or adolescents).
This systemic, non-purulent inflammatory disease occurs mainly metaphyseal
in long bones, in pelvic bones or as spondylitis and is not as rare as it s
eemed. Basis of the disease is a primarily chronic, sterile, in phase of on
set often monotopic (e.g. clavicle) and later frequently polytopic osteomye
litis, possibly triggered by an immuno-pathological process (e.g. Proprioni
bacterium acnes), and showing histologically plasmacellular invasion and a
sclerosing process in different stages. Association with pustulous dermatos
is (psoriasis, acne, palmo-plantar pustulosis) is found in about 25% of chi
ldren and adolescents and in more than 50% of the adult patients. 5 differe
nts types of distribution of osteomyelitic lesions can be found by using Te
99m-bone scan primarily, of which the "pelvic type" is the most common. Bec
ause of the close neighbourhood of meta-/epiphyseal osteomyelitic focuses,
"sympathetic arthritis" with synovitis is seen frequently. A therapeutic ap
proach with azithromycine and calcitonine is presented.