Inclusion body myositis associated with hepatitis C virus infection

The case of a 77-year-old woman with hepatitis C virus infection with a 5-y ear history of muscle weakness and mild disturbance of gait is reported. St eroid therapy did not improve her symptoms. She developed HCV-related liver cirrhosis and hepatocellular carcinoma, and muscle 2 biopsy revealed inclu sion body myositis. Immunohistochemistry showed that the nonstructural regi on of HCV and 8-hydroxy-2 ' -deoxyguanosine, a of marker of DNA damage by r eactive oxygen species, were present in striated muscle cells of this patie nt.