Jejunal or portal vein infusions of lipids increase hepatic vagal afferentactivity

Jejunal infusions of linoleic acid, corn oil, or caprylic acid significantl y increased hepatic vagal afferent activity, whereas saline infusions were ineffective. The magnitude of response was greatest with either linoleic ac id or corn oil. Hepatic portal infusions of linoleic acid, Liposyn II, or c aprylic acid significantly increased hepatic vagal afferent activity, where as 5% albumin/phosphate buffer vehicle was ineffective. The magnitude of re sponse was greatest with either linoleic acid or Liposyn II. These data sho w that either jejunal or portal infusions of lipids increase activity of he patic vagal afferents and could potentially serve as a complementary and/or alternative substrate to celiac vagal afferents in mediating the effects o f jejunal infusions of lipids in suppressing food intake. NeuroReport 12:31 01-3105 (C) 2001 Lippincott Williams& Wilkins.