Lens epithelium-derived growth factor (LEDGF) delays photoreceptor degeneration in explants of rd/rd mouse retina

Authors
Ahuja, P Caffe, AR Holmqvist, I Soderpalm, AK Singh, DP Shinohara, T van Veen, T
Citation
P. Ahuja et al., Lens epithelium-derived growth factor (LEDGF) delays photoreceptor degeneration in explants of rd/rd mouse retina, NEUROREPORT, 12(13), 2001, pp. 2951-2955
Citations number
30
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
09594965 → ACNP
Volume
12
Issue
13
Year of publication
2001
Pages
2951 - 2955
Database
ISI
SICI code
0959-4965(20010917)12:13<2951:LEGF(D>2.0.ZU;2-V
Abstract
Lens epithelium derived growth factor (LEDGF) has been shown to rescue embr yonic chick photoreceptor cells from serum starvation and heat stress, ligh t damaged photoreceptor cells in Lewis rats, and photoreceptor cells in RCS rats. The aim of our study is to study the rescue effect of LEDGF on photo receptor cells in the rd/rd mouse using our long-term serum free organ cult ure. At the end of this culture period of 21-26 days LEDGF treated rd mouse retina showed an increased photoreceptor survival compared to the untreate d controls. LEDGF has no effect on expression and localization of opsin and arrestin in the rod photoreceptor cells when RPE is present. The protectiv e potency of LEDGF on the retinal photoreceptor cells is similar to that of BDNF. LEDGF is known to activate heat shock proteins (Hsps) and the elevat ed Hsps are also reported to suppress apoptosis. NeuroReport 12:2951-2955 ( C) 2001 Lippincott Williams & Wilkins.